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Ph‐positive chronic myeloid leukemia with loss of the segment distal to M‐bcr
Author(s) -
Pedersen Bent,
Bartram Claus R.,
Nielsen Johan Lanng
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870040115
Subject(s) - breakpoint cluster region , myeloid leukemia , chromosomal translocation , medicine , philadelphia chromosome , chromosome , leukemia , cancer research , biology , genetics , gene , receptor
We describe a patient with chronic myeloid leukemia (CML) and a 22q‐ but no 9q + chromosome. Southern blot analysis showed a BCR rearrangement. The patient soon developed profound and superficial thrombophlebitis in arms and legs and died from pulmonary embolisation 15 days after diagnosis. Five CML cases with a deletion of 22q but no known translocation of 22qll → qter have been described earlier. The present patient is the first such case, however, in whom a BCR rearrangement has been demonstrated.