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The nm23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with bg /II
Author(s) -
Varesco Lillana,
Caligo Maria A.,
Nardini Vincenzo,
Bevilacqua Generoso,
Casarino Lucia,
Ferrar Giovanbattista,
Simi Paolo,
Rocchi Mariano,
Black Donald M.,
Solomon Ellen
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870040113
Subject(s) - gene , biology , restriction fragment length polymorphism , genetics , somatic cell , gene mapping , microbiology and biotechnology , chromosome band , chromosome , allele , genotype
The NM23‐HI gene is a putative tumor suppressor gene that may be important in the metastastic process. Recent genetic and immunological data indicate that the NM23‐HI gene encodes a protein with nucleoside diphosphate (NDP) kinase activity. The mapping of NM23‐HI by panels of rodent‐human somatic cell hybrids and in situ hybridization showed that the gene is located in human chromosome band 17q22. A two‐allele polymorphism with Bg /ll was demonstrated.