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Trisomy 2 as the sole chromosomal abnormality in a hepatoblastoma
Author(s) -
Bardi Georgia,
Johansson Bertil,
Pandis Nikos,
Heim Sverre,
Mandahl Nils,
Mitelman Felix,
Békássy Albert,
Hägerstrand Inga
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870040111
Subject(s) - hepatoblastoma , trisomy , karyotype , abnormality , chromosomal abnormality , chromosome 20 , chromosome , biology , chromosome abnormality , trisomy 8 , pathology , genetics , medicine , gene , psychiatry
Short‐term cultures of a fine‐needle aspirate from a hepatoblastoma were analyzed cytogenetically. Trisomy 2 was found as the sole abnormality, yielding the karyotype 47,XY, + 2/46,XY. Because trisomy for all or part of chromosome 2 has been described, although together with other aberrations, in seven of the 11 hepatoblastomas hitherto reported, the finding of +2 as the only anomaly in the present case strongly indicates that additional chromosome 2 material is of pathogenetic significance in this tumor type.