Trisomy 2 as the sole chromosomal abnormality in a hepatoblastoma | Zendy

Bardi Georgia | Zendy; Johansson Bertil | Zendy; Pandis Nikos | Zendy; Heim Sverre | Zendy; Mandahl Nils | Zendy; Mitelman Felix | Zendy; Békássy Albert | Zendy; Hägerstrand Inga | Zendy

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Trisomy 2 as the sole chromosomal abnormality in a hepatoblastoma

Author(s) -

Bardi Georgia,

Johansson Bertil,

Pandis Nikos,

Heim Sverre,

Mandahl Nils,

Mitelman Felix,

Békássy Albert,

Hägerstrand Inga

Publication year - 1992

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.2870040111

Subject(s) - hepatoblastoma , trisomy , karyotype , abnormality , chromosomal abnormality , chromosome 20 , chromosome , biology , chromosome abnormality , trisomy 8 , pathology , genetics , medicine , gene , psychiatry

Short‐term cultures of a fine‐needle aspirate from a hepatoblastoma were analyzed cytogenetically. Trisomy 2 was found as the sole abnormality, yielding the karyotype 47,XY, + 2/46,XY. Because trisomy for all or part of chromosome 2 has been described, although together with other aberrations, in seven of the 11 hepatoblastomas hitherto reported, the finding of +2 as the only anomaly in the present case strongly indicates that additional chromosome 2 material is of pathogenetic significance in this tumor type.

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