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Clonal aberrations of chromosomes x, y, 7 and 10 in normal kidney tissue of patients with renal cell tumors
Author(s) -
Emanuel Angela,
Szucs Sandor,
Weier HeinzUlrich G.,
Kovacs Gyula
Publication year - 1992
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870040110
Subject(s) - renal cell carcinoma , biology , trisomy , kidney , chromosome , microbiology and biotechnology , pathology , karyotype , cell , fluorescence in situ hybridization , cancer research , genetics , medicine , gene
Abstract By means of G‐banding techniques, chromosome aberrations were studied in short‐term cultures of normal renal parenchymal cells from 45 patients with renal cell carcinoma. Clonal chromosomal aberrations were detected in 29 patients; loss of the Y chromosome as well as trisomy X, 5, 7, 9, 10, 12, and 18 was found. Chromosomes 7 and 10 were involved preferentially. Results of fluorescence in situ hybridization with chromosome 7‐ and 10‐specific DNA probes on non‐cultured normal kidney cells suggested that the aberrations developed in vivo.