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Analysis of Chromosome Band Ip36 Alterations by Chromosomal In Situ Suppression Hybridization With a Microclone DNA Bank
Author(s) -
Zink Daniele,
Weith Andreas,
Martinsson Tommy,
Schwab Manfred
Publication year - 1991
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870030514
Subject(s) - microdissection , chromosomal translocation , biology , in situ hybridization , chromosome , fluorescence in situ hybridization , chromosomal abnormality , in situ , genetics , microbiology and biotechnology , karyotype , gene , chemistry , gene expression , organic chemistry
Alterations of the distal portion of chromosome 1p are a recurrent abnormality of several types of human cancer. In this study we show that chromosomal in situ suppression hybridization with a regional 1p36 DNA bank generated by microdissection and microcloning can be employed to detect translocations involving 1p36.