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t(18;22)(q21;q11) with rearrangement of BCL2 as a possible secondary change in a lymphocytic lymphoma
Author(s) -
Leroux Dominique,
Hillion Josette,
Monteil Michele,
Marc'hadour Francois Le,
Jacob MarieChristine,
Sotto Jean Jacques,
Larsen Christian Jacques
Publication year - 1991
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870030306
Subject(s) - chronic lymphocytic leukemia , chromosomal translocation , trisomy , follicular lymphoma , lymphoma , biology , gene rearrangement , microbiology and biotechnology , gene , cancer research , genetics , leukemia , immunology
We report a lymphocytic lymphoma showing a combination of two characteristic neoplasia‐associated chromosomal changes: trisomy 12, commonly observed in chronic lymphocytic leukemia and lymphocytic lymphoma, and t(18;22)(q21;q11), a variant form of the t( 14; 18)(q32;q21) found in most follicular lymphomas. Southern blot analysis was performed using probes for the 5′ end of the BCL2 gene (18q21) and for the JX as well as CX immunoglobulin genes (22q11). With these two probes, a unique rearranged fragment was detected. Thus the t(18;22)(q21;q11) can be considered as a variant translocation of t( 14; 18)(q32;q21). The karyotypic analysis supports the assumption that in our case trisomy 12 occurred first, and t(18;22) appeared during tumor progression as part of the clonal evolution. This is at variance with the typical t( 14; 18), which has never been found to occur as a secondary change.