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Chromosome abnormalities in breast fibroadenomas
Author(s) -
Calabrese Giuseppe,
Virgilio Clemente Di,
Cianchetti Ettore,
Franchi Paolo Guanciali,
Stuppia Liborio,
Parruti Giustino,
Bianchi Patrizia Grace,
Palka Giandomenico
Publication year - 1991
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870030305
Subject(s) - fibroadenoma , chromosome , medicine , pathology , cancer research , genetics , biology , breast cancer , gene , cancer
A cytogenetic study on 25 breast fibroadenomas from 17 women is reported. Seven tumors in five patients showed clonal structural chromosome changes. In three patients the breaks involved chromosome 12, occurring in two tumors in band 12p 12 and in band 12q 15 in all three tumors of one patient. The finding of an identical aberration, t(11;12)(q21;q15), in three adenomas from the same patient strongly suggests a clonal origin of multiple fibroadenomas of the breast.