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Karyotypic evolution in B‐cell chronic lymphocytic leukaemia
Author(s) -
Oscier David,
Fitchett Margaret,
Herbert Tony,
Lambert Richard
Publication year - 1991
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870030104
Subject(s) - karyotype , biology , somatic evolution in cancer , cytogenetics , incidence (geometry) , abnormality , disease , peripheral blood , chromosome , pathology , immunology , genetics , medicine , cancer , physics , psychiatry , gene , optics
Sequential cytogenetic studies were performed on a minimum of two and a maximum of nine occasions (mean 3.6) on the peripheral blood leucocytes of 112 patients with B‐CLL. On initial cytogenetic analysis, 58 had a normal karyotype and 64 had a clonal abnormality. Karyotypic evolution occurred in 18 patients (16%). There was no significant difference in the incidence of disease progression between patients with a stable karyotype and those who underwent karyotypic evolution. In only one patient was there a clear association between disease progression, a change in cell morphology and karyotypic evolution.