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Breast cancer and other cancers in Norwegian families with ataxia‐telangiectasia
Author(s) -
Børresen AnneLise,
Andersen Tone Ikdahl,
Tretli Steinar,
Heiberg Arvid,
Møller Pål
Publication year - 1990
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870020412
Subject(s) - norwegian , ataxia telangiectasia , medicine , breast cancer , oncology , cancer , dermatology , biology , genetics , dna , philosophy , linguistics , dna damage
Patients who are homozygous for ataxia‐telangiectasia (AT) have an exceptionally high incidence of cancer. Heterozygous individuals for the disease have been reported to be at an increased risk of cancer, particularly breast cancer in female carriers. We have analyzed eight Norwegian families with AT for cancer incidence in the parents, in the parents' sibs, grandparents, and grandparents' sibs. Two of the obligate heterozygote females have had premenopausal breast cancer. This incidence is significantly higher than expected for that group. No increase in the cancer incidence was observed in the parents' sibs, the grandparents, or the grandparents' sibs. Since the incidence of AT is low, data from many sources have to be combined to allow any conclusion.