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Monosomy 20: A nonrandom finding in childhood acute lymphoblastic leukemia
Author(s) -
Betts David R.,
Kingston Judith E.,
Dorey Elaine L.,
Young Bryan D.,
Webb David,
Katz Fay E.,
Gibbons Barbara
Publication year - 1990
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870020303
Subject(s) - monosomy , lymphoblastic leukemia , abnormality , pediatrics , medicine , leukemia , complete remission , karyotype , oncology , chromosome , chemotherapy , biology , genetics , psychiatry , gene
We describe four cases of childhood acute lymphoblastic leukemia with monosomy 20 as the sole cytogenetic abnormality. These cases represent 3.4% of cytogenetically abnormal childhood ALL studied in our institute at diagnosis. The patients presented at similar age, ranging from 31 to 36 months. All four patients remain in first remission with survival time being at least 20 months from the time of diagnosis.