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RAS gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study
Author(s) -
Vogelstein Bert,
Civin Curt I.,
Preisinger Antonette C.,
Krischer Jeffrey P.,
Steuber Philip,
Ravindranath Y.,
Weinstein Howard,
Ellferich Peter,
Bos Johannes
Publication year - 1990
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870020212
Subject(s) - neuroblastoma ras viral oncogene homolog , hras , kras , myeloid leukemia , gene , cancer research , mutation , gene mutation , leukemia , myeloid , biology , medicine , genetics
Mutations at codon 12, 13, and 61 of the HRAS, KRAS , and NRAS genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty‐four mutations were identified in the NRAS gene, 13 in the KRAS gene, and none in the HRAS gene. The mutations occurred in a broad spectrum of cases, and there was no specific association of RAS gene mutations with patient subsets defined on the basis of clinical or hematologic features. These data demonstrate that RAS gene mutations are at least as common in childhood AML as in adult AML and suggest that RAS gene mutations play a role in myeloid neoplasia in both age groups.