Premium
Trisomy 12 is a consistent chromosomal aberration in benign ovarian tumors
Author(s) -
Pejovic Tanja,
Heim Sverre,
Mandahl Nils,
Elmfors Bengt,
Flodérus UllaMaria,
Furgyik Stefan,
Helm Góran,
Willén Helena,
Mitelman Felix
Publication year - 1990
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870020109
Subject(s) - pathology , serous cystadenoma , trisomy , cystadenoma , mucinous cystadenoma , ovarian tumor , karyotype , biology , trisomy 8 , serous fluid , ovary , chromosome , medicine , ovarian cancer , cancer , genetics , pancreas , gene , biochemistry
Clonal karyotypic abnormalities were detected in 7 of 42 cytogenetically analyzed benign ovarian tumors. An adenofibroma had –X and a mucinous cystadenoma had t(1;11)(q25;q23) as the sole abnormality. Trisomy 12 was found in the remaining five tumors. It was the only change in two fibromas and a serous cystadenoma; the fourth tumor, a mucinous cystadenoma, had one clone with + 12 and one with + 12 and + 10, and the fifth tumor, a fibrothecoma, had +4, +9, +12. The finding of trisomy 12 in five of seven karyotypically aberrant tumors suggests that this aberration characterizes a hitherto unrecognized cytogenetic subgroup of benign ovarian neoplasms.