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Karyotypic changes identified by Hae III restriction endonuclease banding in a patient with M2 acute non‐lymphoblastic leukemia
Author(s) -
Stuppia Liborio,
Palka Giandomenico,
Fioritoni Giuseppe,
Calabrese Giuseppe,
Franchi Paolo Guanciali,
D'Arcangelo Luigi,
Torlontano Glauco
Publication year - 1990
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870010408
Subject(s) - karyotype , restriction enzyme , lymphoblastic leukemia , chromosomal translocation , microbiology and biotechnology , biology , breakpoint , chromosome , genetics , leukemia , dna , gene
Abstract A patient with acute non‐lymphoblastic leukemia, FAB type M2, showed a complex karyotype involving chromosomes 1 and 11. The breakpoints could not be exactly identified by GTG and QFQ banding. A subsequent analysis with AluI and Hae III restriction enzyme staining allowed the detection of a translocation of the heterochromatic region of chromosome 1 to 11q21.