Karyotypic changes identified by  Hae III restriction endonuclease banding in a patient with M2 acute non‐lymphoblastic leukemia | Zendy

Stuppia Liborio | Zendy; Palka Giandomenico | Zendy; Fioritoni Giuseppe | Zendy; Calabrese Giuseppe | Zendy; Franchi Paolo Guanciali | Zendy; D'Arcangelo Luigi | Zendy; Torlontano Glauco | Zendy

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Karyotypic changes identified by Hae III restriction endonuclease banding in a patient with M2 acute non‐lymphoblastic leukemia

Author(s) -

Stuppia Liborio,

Palka Giandomenico,

Fioritoni Giuseppe,

Calabrese Giuseppe,

Franchi Paolo Guanciali,

D'Arcangelo Luigi,

Torlontano Glauco

Publication year - 1990

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.2870010408

Subject(s) - karyotype , restriction enzyme , lymphoblastic leukemia , chromosomal translocation , microbiology and biotechnology , biology , breakpoint , chromosome , genetics , leukemia , dna , gene

A patient with acute non‐lymphoblastic leukemia, FAB type M2, showed a complex karyotype involving chromosomes 1 and 11. The breakpoints could not be exactly identified by GTG and QFQ banding. A subsequent analysis with AluI and Hae III restriction enzyme staining allowed the detection of a translocation of the heterochromatic region of chromosome 1 to 11q21.

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