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Consistent occurrence of a 19p+ marker chromosome and loss of 11p material in ovarian seropapillary cystadenocarcinomas
Author(s) -
Pejovic Tanja,
Heim Sverre,
Mandahl Nils,
Elmfors Bengt,
Flodérus UllaMaria,
Furgyik Stefan,
Helm Göran,
Willén Helena,
Mitelman Felix
Publication year - 1989
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870010210
Subject(s) - chromosome , biology , pathology , cancer research , genetics , medicine , gene
Cytogenetic analysis of short‐term cultures from 11 moderately to poorly differentiated ovarian seropapillary cystadenocarcinomas revealed clonal chromosomal abnormalities in nine tumors. Two bands were involved in structural rearrangements in more than half of the tumors. The band most frequently affected was 19p13; rearrangements giving rise to a 19p+ marker chromosome were found in seven tumors, and in four of them the 19p+ markers appeared to be identical. Structural rearrangements resulting in loss of 11p13‐11pter material were found in six tumors.