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Human PDGFA receptor gene maps to the same region on chromosome 4 as the KIT oncogene
Author(s) -
Stenman Göran,
Eriksson Anders,
ClaessonWelsh Lena
Publication year - 1989
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870010208
Subject(s) - pdgfb , biology , chromosome 22 , chromosome 4 , chromosome , microbiology and biotechnology , chromosome 15 , platelet derived growth factor receptor , chromosome 12 , growth factor receptor , gene , genetics , chromosome 17 (human) , cancer research , receptor , growth factor
The gene for the human platelet‐derived growth factor ( PDGF ) A type receptor was assigned to the proximal long arm of chromosome 4 by using in situ hybridization. Of 141 labeled metaphase cells, 74 had grains over chromosome 4, with a distinct peak at bands q11q–q12. The presence of the gene on chromosome 4 was also confirmed by hybridization to chromosome specific libraries. This places the PDGFA receptor gene in the same region of chromosome 4 as the KIT oncogene, another member of the PDGF growth factor receptor subfamily. The two other members of this gene family, the PDGFB receptor and the colony stimulating factor‐1 ( CSF1 ) receptor, are closely linked on the distal half of the long arm of chromosome 5.