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Premature chromosome condensation in childhood acute lymphoblastic leukaemia: Correlation of proliferative potential index in blood and marrow
Author(s) -
Macleod Roderick A. F.,
Hill Frank G. H.,
Creasy Michael R.,
Hulten Maj A.
Publication year - 1989
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870010205
Subject(s) - correlation , bone marrow , premature chromosome condensation , index (typography) , childhood leukaemia , medicine , chromosome , biology , immunology , genetics , pediatrics , mathematics , computer science , world wide web , gene , geometry
The proliferative potential index (PPI), which is the proportion of all G1 cells which are in late G1, has been shown to reflect disease state in patients with acute leukaemia. We have determined PPI in paired blood and marrow samples from children with acute lymphoblastic leukaemia (ALL) at different stages of the disease, and found a close correlation between blood and marrow PPI irrespective of disease stage. Therefore blood PPI can replace marrow PPI for monitoring disease control in ALL.