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Complex karyotypic anomalies in a bizarre leiomyoma of the uterus
Author(s) -
Nilbert Mef,
Heim Sverre,
Mandahl Nils,
Flodérus UllaMaria,
Willén Helena,
Baldetorp Bo,
Mitelman Felix
Publication year - 1989
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870010204
Subject(s) - karyotype , biology , clone (java method) , flow cytometry , microbiology and biotechnology , uterus , ploidy , chromosome , cytogenetics , pathology , genetics , dna , gene , medicine
Abstract Cytogenetic investigation of short‐term cultures from a bizarre leiomyoma of the uterus, a tumor type not hitherto karyotypically characterized, revealed two abnormal clones with multiple complex rearrangements. Three‐fourths of the aberrant cells were hypodiploid with the composite karyotype 38–44, XX,−6,−7,−10,−11,+20,−22, r(1), der(2) (:2p23→cen→2q13::1q21→1qter), der(2)t(2;9)(p21;q13), t(5;?)(q35;?), t(5;?),(q35;?), + der(5)t(5;15)(q11;q15), der(8)t(8;11)(q24;q13), t(15;?)(p12;?), der(16)t(12;16)(q13;p13),+r,+mar. The remaining abnormal mitoses were hypotetraploid, with chromosome numbers ranging from 74 to 86. These massively rearranged cells showed the same markers that were found in the hypodiploid clone, but in duplicate, indicating that this clone had arisen through polyploidization of hypodiploid cells. Flow cytometry revealed a DNA index of 1.03.