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Leukemic differentiation of a mediastinal germ cell tumor
Author(s) -
Chaganti R. S. K.,
Ladanyi Marc,
Samaniego Felipe,
Offit Kenneth,
Reuter Victor E.,
Jhanwar Suresh C.,
Bosl George J.
Publication year - 1989
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.2870010113
Subject(s) - clone (java method) , germ cell tumors , yolk sac , leukemia , pathology , germ cell , immature teratoma , biology , bone marrow , trisomy , trisomy 8 , cancer research , medicine , cytogenetics , immunology , chromosome , embryo , chemotherapy , genetics , gene
The biological basis for acute leukemia associated with mediastinal germ cell tumors has remained unexplained due to lack of critical data that would illuminate the genetic relationship between the two tumors in a given patient. Here we present results of serial cytogenetic investigations on the pretreatment and posttreatment mediastinal yolk sac tumor and immature teratoma biopsies and two separate leukemic bone marrow aspirates from a patient who developed acute nonlymphocytic leukemia 11 months after the initial diagnosis of the germ cell tumor. Presence of an i(12p) in all tumor clones and trisomy 21 in one clone in the posttreatment mediastinal tumor and all leukemic clones establishes the common origin of all tumor clones and shows that in this case the leukemia was derived from the malignant germ cell clone.