Premium
Update on SWI / SNF ‐related gynecologic mesenchymal neoplasms: SMARCA4 ‐deficient uterine sarcoma and SMARCB1 ‐deficient vulvar neoplasms
Author(s) -
Howitt Brooke E.,
Folpe Andrew L.
Publication year - 2021
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.22922
Subject(s) - smarca4 , smarcb1 , chromatin remodeling , swi/snf , epithelioid sarcoma , cancer research , medicine , biology , chromatin , sarcoma , pathology , gene , genetics
Our knowledge regarding the role of genes encoding the chromatin remodeling switch/sucrose non‐fermenting (SWI/SNF) complex in the initiation and progression of gynecologic malignancies continues to evolve. This review focuses on gynecologic tumors in which the sole or primary genetic alteration is in SMARCA4 or SMARCB1 , two members of the SWI/SNF chromatin remodeling complex. In this review, we present a brief overview of the classical example of such tumors, ovarian small cell carcinoma of hypercalcemic type, and then a detailed review and update of SMARCB1‐deficient and SMARCA4‐deficient tumors of the uterus and vulva.