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Identification of a novel KMT2A / GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia
Author(s) -
Berg Holly E.,
Blackburn Patrick R.,
Baughn Linda B.,
Ketterling Rhett P.,
Xu Xinjie,
Greipp Patricia T.,
Hoppman Nicole L.,
Smadbeck James B.,
Vasmatzis George,
Shi Min,
Reichard Kaaren K.,
Viswanatha David S.,
Jevremovic Dragan,
Maher George M.,
Peterson Jess F.
Publication year - 2021
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.22902
Subject(s) - gene rearrangement , myeloid leukemia , fusion gene , gene , leukemia , identification (biology) , biology , cancer research , genetics , botany
Acute undifferentiated leukemia (AUL) is a very rare hematologic neoplasm that expresses no markers specific for either myeloid or lymphoid lineages. While commonly observed in several acute leukemias, KMT2A rearrangements in AUL have been rarely reported in the literature. We report the third case to our knowledge of AUL harboring a KMT2A rearrangement. Furthermore, the KMT2A/GIMAP8 gene fusion identified in this case represents a novel KMT2A rearrangement.