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Functional mechanisms of miR ‐192 family in cancer
Author(s) -
Mishan Mohammad Amir,
Tabari Mohammad Amin Khazeei,
Parnian Javad,
Fallahi Jafar,
Mahrooz Abdolkarim,
Bagheri Abouzar
Publication year - 2020
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.22889
Subject(s) - microrna , biology , biomarker , cancer , computational biology , cancer research , gene , genetics
By growing research on the mechanisms and functions of microRNAs (miRNAs, miRs), the role of these noncoding RNAs gained more attention in healthcare. Due to the remarkable regulatory role of miRNAs, any dysregulation in their expression causes cellular functional impairment. In recent years, it has become increasingly apparent that these small molecules contribute to development, cell differentiation, proliferation, apoptosis, and tumor growth. In many studies, the miR‐192 family has been suggested as a potential prognostic and diagnostic biomarker and even as a possible therapeutic target for several cancers. However, the mechanistic effects of the miR‐192 family on cancer cells are still controversial. Here, we have reviewed each family member of the miR‐192 including miR‐192, miR‐194, and miR‐215, and discussed their mechanistic roles in various cancers.