English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Papillary thyroid carcinoma (PTC) is most common among all thyroid cancers. Multiple genomic alterations occur in PTC, and gene rearrangements are one of them. Here we screened 14 tumors for novel fusion transcripts by RNA‐Seq. Two samples harboring  RET/PTC1  and  RET/PTC3  rearrangements were positive controls whereas the remaining ones were negative regarding the common PTC alterations. We used Sanger sequencing to validate potential fusions. We detected 2 novel potentially oncogenic transcript fusions:  TG‐FGFR1  and  TRIM33‐NTRK1 . We detected 4 novel fusion transcripts of unknown significance accompanying the  TRIM33‐NTRK1  fusion:  ZSWIM5‐TP53BP2 ,  TAF4B‐WDR1 ,  ABI2‐MTA3 , and  ARID1B‐PSMA1 . Apart from confirming the presence of  RET/PTC1  and  RET/PTC3  in positive control samples, we also detected known oncogenic fusion transcripts in remaining samples:  TFG‐NTRK1 ,  ETV6‐NTRK3 ,  MKRN1‐BRAF ,  EML4‐ALK , and novel isoform of  CCDC6‐RET .

Novel TG‐FGFR1 and TRIM33‐NTRK1 transcript fusions in papillary thyroid carcinoma