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Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer
Author(s) -
Fritz A.J.,
Gillis N.E.,
Gerrard D.L.,
Rodriguez P.D.,
Hong D.,
Rose J.T.,
Ghule P.N.,
Bolf E.L.,
Gordon J.A.,
Tye C.E.,
Boyd J.R.,
Tracy K.M.,
Nickerson J.A.,
Wijnen A.J.,
Imbalzano A.N.,
Heath J.L.,
Frietze S.E.,
Zaidi S.K.,
Carr F.E.,
Lian J.B.,
Stein J.L.,
Stein G.S.
Publication year - 2019
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.22731
Subject(s) - epigenetics , chromatin , breast cancer , biology , cancer , bookmarking , histone , cancer research , computational biology , bioinformatics , genetics , gene
Cells establish and sustain structural and functional integrity of the genome to support cellular identity and prevent malignant transformation. In this review, we present a strategic overview of epigenetic regulatory mechanisms including histone modifications and higher order chromatin organization (HCO) that are perturbed in breast cancer onset and progression. Implications for dysfunctions that occur in hormone regulation, cell cycle control, and mitotic bookmarking in breast cancer are considered, with an emphasis on epithelial‐to‐mesenchymal transition and cancer stem cell activities. The architectural organization of regulatory machinery is addressed within the contexts of translating cancer‐compromised genomic organization to advances in breast cancer risk assessment, diagnosis, prognosis, and identification of novel therapeutic targets with high specificity and minimal off target effects.