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Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer
Author(s) -
Wang Guan,
Li Xianfeng,
Tian Weiping,
Wang Yan,
Wu Dandan,
Sun Zhongsheng,
Zhao Enfeng
Publication year - 2015
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.22257
Subject(s) - dna methylation , carcinogenesis , ovarian cancer , promoter , gene , cancer research , cpg site , biology , methylation , gene expression , cancer , microbiology and biotechnology , genetics
As a transforming growth factor‐β (TGF‐β)‐inducible gene, the expression of Krüppel‐like transcription factor 11 ( KLF11 ) is altered in several types of cancer. In the current study, through using human 9K CpG island array, KLF11 was identified as one of hypermethylated genes in RAS‐transformed ovarian T29H cells. Methylation of the KLF11 promoter was also observed in ovarian cancer tissue samples accompanied by significantly reduced KLF11 gene expression. Interestingly, the expression of SMAD2 , SMAD3, and SMAD7 genes was reduced in the tumour, whilst no change was found in TGF‐β expression. Our data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis. © 2015 Wiley Periodicals, Inc.