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Ploidy and clinical characteristics of childhood acute myeloid leukemia: A NOPHO‐AML study
Author(s) -
Sandahl Julie Damgaard,
Kjeldsen Eigil,
Abrahamsson Jonas,
Ha ShauYin,
Heldrup Jesper,
Jahnukainen Kirsi,
Jónsson Ólafur G.,
Lausen Birgitte,
Palle Josefine,
Zeller Bernward,
Forestier Erik,
Hasle Henrik
Publication year - 2014
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.22177
Subject(s) - myeloid leukemia , karyotype , medicine , gastroenterology , myeloid , population , biology , oncology , immunology , chromosome , genetics , environmental health , gene
We report the first large series ( n = 596) of pediatric acute myeloid leukemia (AML) focusing on modal numbers (MN) from the population‐based NOPHO‐AML trials. Abnormal karyotypes were present in 452 cases (76%) and numerical aberrations were present in 40% ( n = 237) of all pediatric AML. Among patients with an abnormal karyotype, the MN 46 was most common ( n = 251; 56%) of which 36 (8%) were pseudodiploid with numerical aberrations, followed by MN 47 ( n = 80; 18%) and MN 43–45 ( n = 48; 8%). No cases had MN less than 43. Hyperdiploid AML with MN 48–65 comprised 11% of all cases and was associated with early onset (median age 2 years), female sex (57%), and a dominance of acute megakaryoblastic leukemia (AMKL) (29%). Hypodiploidy constituted 8% of all AML and was associated with older age (median age 9 years), male predominance (60%), FAB M2 (56%), and t(8;21)(q22;q22) (56%) with loss of sex chromosomes. Inferior outcome was observed for hypodiploid cases (5‐year event‐free survival 40% and 5‐year overall survival 40%) but did not reach statistical significance. Chromosomes were gained in a nonrandom pattern, where chromosomes 8, 21, 19, and 6 were the most commonly gained. In conclusion, based on MNs, two cytogenetic subgroups with characteristic clinical features are described; hypodiploidy found in 8% and associated with high median age, male sex, t(8;21)(q22;q22), and FAB M2 and possibly associated with inferior outcome ( P = 0.13), and hyperdiploidy with MN 48–65 in 11% associated with early onset, female sex, and AMKL. © 2014 Wiley Periodicals, Inc.