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Genetic score of multiple risk‐associated single nucleotide polymorphisms is a marker for genetic susceptibility to bladder cancer
Author(s) -
Wang Ping,
Ye Dingwei,
Guo Jianming,
Liu Fang,
Jiang Haowen,
Gong Jian,
Gu Chengyuan,
Shao Qiang,
Sun Jielin,
Zheng S. Lilly,
Yu Hongjie,
Lin Xiaoling,
Xia Guowei,
Fang Zujun,
Zhu Yao,
Ding Qiang,
Xu Jianfeng
Publication year - 2014
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.22121
Subject(s) - single nucleotide polymorphism , bladder cancer , medicine , confidence interval , genetic model , oncology , genetic predisposition , population , cancer , genotype , biology , genetics , gene , disease , environmental health
Genome‐wide association studies have identified 13 single nucleotide polymorphisms (SNPs) that are associated with bladder cancer; three of these SNPs were validated in the Chinese population. This study assessed the performance of these three SNPs, in combination, to predict genetic susceptibility to bladder cancer in Chinese. Three previously established bladder cancer risk‐associated SNPs (rs798766 in TACC3 , rs9642880 in MYC , and rs2294008 in PSCA ) were genotyped in 1,210 bladder cancer patients and 1,008 control subjects in Shanghai, China. A genetic score was calculated for each subject based on these three SNPs. Each of these three SNPs was significantly associated with bladder cancer risk in this independent study population, P < 0.05. The genetic score based on these three SNPs was significantly higher in cases than controls, with a mean of 1.05 and 0.99, respectively, P = 1.03E‐05. Compared with subjects with a genetic score <= 1.00, subjects with an elevated genetic score (>1.00) had a significantly increased risk for bladder cancer after adjusting for age, gender, and smoking status, OR = 1.58, 95% Confidence Interval (CI) = 1.21 − 2.06, P = 0.0007. When tested separately for lower (Ta) or higher (Tis, T1‐T4) tumor stage, the association was significantly stronger for lower (OR = 2.24, 95% CI = 1.66 − 3.01, P = 1.02E‐07) than higher tumor stage (OR = 1.33, 95% CI = 1.00 − 1.78, P = 0.05), P = 0.001. In conclusion, A combination of three previously implicated bladder cancer risk‐associated SNPs is a significant predictor of genetic susceptibility to bladder cancer in Chinese. © 2013 Wiley Periodicals, Inc.