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The characteristics and clinical outcome of adult patients with aplastic anemia and abnormal cytogenetics at diagnosis
Author(s) -
Kim SungYong,
Lee JongWook,
Lee SungEun,
Cho ByungSik,
Kim Myungshin,
Eom KiSeong,
Kim YooJin,
Kim HeeJe,
Lee Seok,
Min ChangKi,
Cho SeokGoo,
Kim DongWook,
Han Kyungja,
Min WooSung
Publication year - 2010
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.20793
Subject(s) - cytogenetics , monosomy , aplastic anemia , trisomy 8 , medicine , gastroenterology , pathology , biology , karyotype , chromosome , bone marrow , genetics , gene
Abstract The characteristics and clinical outcome of 600 adult patients with aplastic anemia (AA) that had successful cytogenetic studies at the time of diagnosis were retrospectively evaluated. Among these, 572 (95.3%) had normal cytogenetics and 28 (4.7%) had abnormal cytogenetics. The most frequent abnormality was trisomy 8 ( n = 15), followed by monosomy 7/deletion of 7q ( n = 5), and deletion of 1q ( n = 5). There were no statistically significant differences with respect to gender, hepatitis viral infection, paroxysmal nocturnal hemoglobinuria, or severity of disease between the patients in the normal and abnormal cytogenetics groups; however, the patients with abnormal cytogenetics were generally younger than those with normal cytogenetics ( P < 0.001). Abnormal cytogenetics was associated with a higher cumulative leukemic transformation rate ( P < 0.001) and lower leukemic transformation‐free survival ( P = 0.021). Furthermore, abnormal cytogenetics was an independent predictor of a poor response to immunosuppressive therapy (HR = 0.255; 95% CI = 0.077–0.839; P = 0.024). These analyses suggest that patients with AA and abnormal cytogenetics have different clinical characteristics compared to patients with AA and normal cytogenetics. © 2010 Wiley‐Liss, Inc.