High incidence of familial breast cancer segregates with constitutional t(11;22)(q23;q11) | Zendy

Wieland Ilse | Zendy; Muschke Petra | Zendy; Volleth Marianne | Zendy; Röpke Albrecht | Zendy; Pelz AntjeFriederike | Zendy; Stumm Markus | Zendy; Wieacker Peter | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

High incidence of familial breast cancer segregates with constitutional t(11;22)(q23;q11)

Author(s) -

Wieland Ilse,

Muschke Petra,

Volleth Marianne,

Röpke Albrecht,

Pelz AntjeFriederike,

Stumm Markus,

Wieacker Peter

Publication year - 2006

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.20358

Subject(s) - chromosomal translocation , loss of heterozygosity , breast cancer , breakpoint , incidence (geometry) , biology , chromosome , cancer research , cancer , oncology , medicine , genetics , gene , allele , physics , optics

In a family with a high incidence of postmenopausal breast cancer and a case of glioblastoma, the constitutional translocation t(11;22)(q23;q11.2) was shown to segregate with the malignancies. The breakpoints in this family coincided with the common breakpoints in t(11;22) as shown by a translocation‐specific PCR assay. Loss of heterozygosity analysis of breast tumor tissue revealed deletion of the normal chromosome 22, but retention of der(22) in the tumor cells, suggesting a predisposing effect of the der(22) for breast and brain tumor development in this family. © 2006 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research