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High incidence of familial breast cancer segregates with constitutional t(11;22)(q23;q11)
Author(s) -
Wieland Ilse,
Muschke Petra,
Volleth Marianne,
Röpke Albrecht,
Pelz AntjeFriederike,
Stumm Markus,
Wieacker Peter
Publication year - 2006
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.20358
Subject(s) - chromosomal translocation , loss of heterozygosity , breast cancer , breakpoint , incidence (geometry) , biology , chromosome , cancer research , cancer , oncology , medicine , genetics , gene , allele , physics , optics
In a family with a high incidence of postmenopausal breast cancer and a case of glioblastoma, the constitutional translocation t(11;22)(q23;q11.2) was shown to segregate with the malignancies. The breakpoints in this family coincided with the common breakpoints in t(11;22) as shown by a translocation‐specific PCR assay. Loss of heterozygosity analysis of breast tumor tissue revealed deletion of the normal chromosome 22, but retention of der(22) in the tumor cells, suggesting a predisposing effect of the der(22) for breast and brain tumor development in this family. © 2006 Wiley‐Liss, Inc.