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Chromosomal losses of regions on 5q and lack of high‐level amplifications at 8q24 are associated with favorable prognosis for ovarian serous carcinoma
Author(s) -
Staebler Annette,
Karberg Bianca,
Behm Juliane,
Kuhlmann Petra,
Neubert Ulrike,
Schmidt Hartmut,
Korsching Eberhard,
Bürger Horst,
Lelle Ralph,
Kiesel Ludwig,
Böcker Werner,
Shih IeMing,
Buchweitz Olaf
Publication year - 2006
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.20356
Subject(s) - serous fluid , comparative genomic hybridization , serous carcinoma , tumor progression , incidence (geometry) , medicine , gastroenterology , pathology , stage (stratigraphy) , tumor grade , carcinoma , biology , oncology , cancer , ovarian cancer , gene , genetics , paleontology , physics , genome , optics
Abstract In this study, we describe characteristic chromosomal alterations in a consecutive series of 96 serous ovarian tumors by comparative genomic hybridization. We analyze their association with different pathways of progression, histological grade, and clinical outcome. The most striking difference between low‐grade and high‐grade serous carcinomas was seen in a higher incidence of chromosomal gains at 3q and 20q and losses of 13q in the high‐grade carcinomas. In addition, high‐level amplifications were significantly more frequent in high‐grade carcinomas, specifically involving regions on 3q and 8q. Chromosomal amplifications of 19p and 19q and losses of 4q and 5q were among the most frequent changes found in both low‐grade and high‐grade carcinomas, distinguishing them from borderline tumors, which had very few recurrent alterations. The most significant impact on survival of patients with invasive carcinomas Stage II–IV was observed for high‐level amplifications of regions on 8q (mean overall survival (OS) 69 versus 27 months, P = 0.0006). Interestingly, low‐level gains on 8q do not show any impact compared to cases with no alteration. Surprisingly, chromosomal losses on 5q had a protective impact (mean OS 36 versus 76 months, P = 0.0007). Combination of both parameters resulted in two risk groups. Low risk: loss on 5q, no amplification on 8q (mean OS 84 months); high risk: no loss on 5q, amplification on 8q (mean OS 26 months). This difference is even more pronounced, if only cases with residual tumor of less than 2 cm are included, resulting in a 5‐year survival of 100% and 0% ( P = 0.0005). © 2006 Wiley‐Liss, Inc.