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t(3;14)(p14;q32) Results in aberrant expression of FOXP1 in a case of diffuse large B‐cell lymphoma
Author(s) -
Fenton James A. L.,
Schuuring Ed,
Barrans Sharon L.,
Banham Alison H.,
Rollinson Sara J.,
Morgan Gareth J.,
Jack Andrew S.,
van Krieken J. Han. J. M.,
Kluin Philip M
Publication year - 2006
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.20278
Subject(s) - immunoglobulin heavy chain , transcription factor , diffuse large b cell lymphoma , enhancer , locus (genetics) , lymphoma , gene , cancer research , biology , breakpoint , pax5 , gene expression , genetics , chromosomal translocation , immunology
Strong expression of Forkhead box‐P1 (FOXP1), a winged‐helix transcription factor, has been identified as an independent prognostic factor in diffuse large B‐cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain ( IGH ) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers. © 2005 Wiley‐Liss, Inc.