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PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B‐NHL with complex chromosomal rearrangements
Author(s) -
Poppe Bruce,
De Paepe Pascale,
Michaux Lucienne,
Dastugue Nicole,
Bastard Christian,
Herens Christian,
Moreau Els,
Cavazzini Francesco,
Yigit Nurten,
Van Limbergen Heidi,
De Paepe Anne,
Praet Marleen,
De WolfPeeters Chris,
Wlodarska Iwona,
Speleman Frank
Publication year - 2005
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.20214
Subject(s) - gene rearrangement , pax5 , fluorescence in situ hybridization , chromosomal translocation , lymphoma , biology , diffuse large b cell lymphoma , lymphoplasmacytic lymphoma , b cell , immunoglobulin heavy chain , cancer research , pathology , microbiology and biotechnology , gene , immunology , medicine , waldenstrom macroglobulinemia , antibody , genetics , chromosome
We present an extensive characterization of 10 B‐cell lymphomas with a t(9;14)(p13;q32). The presence of the PAX5/IGH gene rearrangement was demonstrated by fluorescence in situ hybridization (FISH) using a validated probe set, whereas complex karyotypic changes were reassessed by multiplex‐FISH (M‐FISH). Pathologic and clinical review revealed the presence of this rearrangement in 4 histiocyte‐rich, T‐cell‐rich B‐cell lymphomas (HRTR‐BCLs) and 2 posttransplantation diffuse large B‐cell lymphomas (PTLD‐DLBCLs). In contrast to initial observations describing this translocation in lymphoplasmacytic lymphoma (LPL) and LPL‐derived large B‐cell lymphoma, our data showed a wide morphologic and clinical spectrum associated with the PAX5/IGH rearrangement, pointing to an association between this aberration and a subset of de novo DLBCLs presenting with advanced disease and adverse prognosis. In addition, the recurrent incidence of this rearrangement in both HRTR‐BCL (4 cases) and PTLD‐DLBCL (2 cases) was previously unrecognized and is intriguing. © 2005 Wiley‐Liss, Inc.