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ETV6 gene rearrangements in invasive breast carcinoma
Author(s) -
Letessier Anne,
Ginestier Christophe,
CharafeJauffret Emmanuelle,
Cervera Nathalie,
Adélaïde José,
GelsiBoyer Véronique,
Ahomadegbe JeanCharles,
Benard Jean,
Jacquemier Jocelyne,
Birnbaum Daniel,
Chaffanet Max
Publication year - 2005
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.20200
Subject(s) - etv6 , fluorescence in situ hybridization , tissue microarray , breast cancer , biology , fish <actinopterygii> , ductal carcinoma , cancer research , in situ hybridization , gene , immunohistochemistry , cancer , pathology , medicine , gene expression , chromosomal translocation , genetics , immunology , chromosome , fishery
The ETV6/TEL gene encodes a transcription factor frequently rearranged in several types of cancer. We looked for ETV6 rearrangements in invasive breast cancer using fluorescence in situ hybridization (FISH) of BAC probes on sections of tissue microarrays containing 632 tumor samples. Of these samples, signal of sufficient quality for screening by FISH was obtained for 356. Five cases (one lobular, one nontypical secretory, one mixed, and two ductal carcinomas) showed ETV6 rearrangement. © 2005 Wiley‐Liss, Inc.