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Ductal breast carcinoma develops through different patterns of chromosomal evolution
Author(s) -
Molist Romain,
GerbaultSeureau Michele,
SastreGarau Xavier,
SigalZafrani Brigitte,
Dutrillaux Bernard,
Muleris Martine
Publication year - 2005
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.20178
Subject(s) - comparative genomic hybridization , biology , chromosome , karyotype , ductal carcinoma , breast carcinoma , invasive ductal carcinoma , carcinoma , genetics , breast cancer , cancer , gene
In a previous study that used comparative genomic hybridization (CGH) to analyze 43 ductal breast carcinomas selected for hyperdiploidy, we proposed the existence of two distinct pathways of chromosomal evolution. In the present study, in which we reassessed our cytogenetic findings on 158 ductal breast carcinomas selected for having a modal number of chromosomes of fewer than 60, we confirmed the existence of two subtypes of tumors. Along with the great majority of tumors (142 of 158) that evolved through structural rearrangements with no or very few whole‐chromosome gains, we found that a minor subset (16 of 158) evolved through progressive gains of whole chromosomes with no or only a few associated rearrangements. In this article, we describe the karyotypes of these 16 tumors together with data from CGH, which was performed for 10 of them. Chromosomes 5, 7, 8, and 20 were the most frequently gained. Our findings support the evidence of a new pathway of chromosomal evolution in a small subset of ductal breast carcinomas characterized by numerical chromosome aberrations. © 2005 Wiley‐Liss, Inc.