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Acute lymphoblastic leukemia in a patient with Greig cephalopolysyndactyly and interstitial deletion of chromosome 7 del(7)(p11.2 p14) involving the GLI3 and ZNFN1A1 genes
Author(s) -
MendozaLondono Roberto,
Kashork Catherine D.,
Shaffer Lisa G.,
Krance Robert,
Plon Sharon E.
Publication year - 2005
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.20100
Subject(s) - gli3 , haploinsufficiency , biology , zinc finger , zinc finger transcription factor , genetics , leukemia , gene , cancer research , transcription factor , repressor , phenotype
Greig cephalopolysyndactyly (GCPS; OMIM 175700) is an autosomal dominant condition caused by mutations of the gene GLI3 , located on 7p13. To date, several cases of deletions and/or translocations involving this locus have been reported in patients with GCPS. GLI3 is a transcription factor from the GLI ‐Kruppel gene family that has been implicated in three distinct entities: GCPS, Pallister–Hall syndrome, and postaxial polydactyly type A. The zinc finger protein, subfamily 1, member 1 gene ( ZNFN1A1 ; OMIM 603023), on 7p12, codes for a lymphoid‐restricted zinc finger transcription factor, ZNFN1A1, also called IKAROS, that regulates lymphocyte differentiation and has been associated with the development of childhood leukemia. We present the case of a 9‐year‐old Latin‐American boy who was referred for stem cell transplantation because of recurrent acute lymphoblastic leukemia (ALL). On evaluation, he was found to have dysmorphic features consistent with GCPS, including a prominent forehead, down‐slanting palpebral fissures, 1‐2‐3 toe syndactyly, broad thumbs and first toes, and mild developmental delay. He had developed ALL at 5 years of age. Chromosome analysis of bone marrow and fibroblastic cells showed an interstitial deletion of chromosome arm 7p, del(7)(p11.2p14), in 74% and 44% of the cells, respectively. We performed FISH analysis with a BAC clone containing the ZNFN1A1 gene and demonstrated that it is contained in the deleted segment. To our knowledge, this is the first report of a patient with GCPS and leukemia. We hypothesize that constitutional deletion of the ZNFN1A1 gene in this patient may have resulted in an increased risk of lymphoid malignancy. © 2005 Wiley‐Liss, Inc.