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Diminished transcription of chromosome arm 4q is inversely related to local spreading of hepatocellular carcinoma
Author(s) -
Dykema Karl J.,
Furge Kyle A.
Publication year - 2004
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.20090
Subject(s) - hepatocellular carcinoma , locus (genetics) , biology , epigenetics , gene , gene expression , transcription (linguistics) , chromosome , portal vein , cancer research , pathology , genetics , medicine , linguistics , philosophy
To identify transcriptional features associated with local spreading of hepatocellular carcinoma (HCC), regional expression biases were determined from the gene expression profiles of solitary HCC tumors and of HCC tumors associated with additional intrahepatic lesions and/or portal vein involvement. Regional expression biases are genetic intervals in which gene expression is coordinately changed. Often, but not always, a regional expression bias indicates an underlying chromosomal aberration. This study demonstrated that the presence or absence of a regional expression bias on chromosome arm 4q can predict the presence or absence of intrahepatic spread/portal vein involvement in 83% of cases analyzed ( n = 40). These results suggest that the transcriptional state of 4q may be a marker for local spreading of HCC and that a more detailed genetic/epigenetic characterization of this locus may provide additional insights into HCC development. © 2004 Wiley‐Liss, Inc.