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Various types of rearrangements target TLX3 locus in T‐cell acute lymphoblastic leukemia
Author(s) -
Su Xin Ying,
Busson Maryvonne,
Della Valle Véronique,
Ballerini Paola,
Dastugue Nicole,
Talmant Pascaline,
Ferrando Adolfo A.,
BaudryBluteau Dominique,
Romana Serge,
Berger Roland,
Bernard Olivier A.
Publication year - 2004
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.20088
Subject(s) - chromosomal translocation , ectopic expression , genetics , biology , breakpoint , locus (genetics) , gene , fusion gene , microbiology and biotechnology
Most chromosomal translocations observed in T‐cell acute lymphoblastic leukemia (T‐ALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the TLX3 (also known as HOX11L2 ) gene has been shown to be associated with a cryptic t(5;14)(q35;q32) translocation specific for a subtype of T‐ALL. Here we report several examples of variant and alternative translocations resulting in expression of TLX3 in T‐ALL, and we describe three of these translocations in detail. In particular, the CDK6 gene was rearranged in two t(5;7)(q35;q21) translocations. In two additional instances, fusion of the BCL11B (also known as CTIP2) and RANBP17/TLX3 loci were shown to result from subtle genomic insertion/deletion within these loci. This study further underscores that TLX3 expression in T‐ALL is strongly associated with the presence of genomic rearrangements. © 2004 Wiley‐Liss, Inc.