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Genetic imbalances in 26 cases of penile squamous cell carcinoma
Author(s) -
Alves Gilda,
Heller Anita,
Fiedler Wolfgang,
Campos Mércia Mendes,
Claussen Uwe,
Ornellas Antônio Augusto,
Liehr Thomas
Publication year - 2001
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.1117
Subject(s) - comparative genomic hybridization , chromosome , basal cell , karyotype , biology , cancer research , pathology , medicine , genetics , gene
To obtain more information on chromosomal changes in the up‐to‐now poorly studied tumor class of penile squamous cell carcinoma (SCC), we performed a comparative genomic hybridization study of 26 cases of this rare tumor. DNA sequence copy number alterations (CNAs) very similar to those detected in other SCC types, such as oral and esophageal SCC, were noted. The most common copy number gains were found in 8q24, 16p11–12, 20q11–13, 22q, 19q13, and 5p15, and the most common deletions were detected in 13q21–22, 4q21–32, and along the X chromosome. Classifying the patients according to the number of CNAs showed a possible correlation with clinical outcome. © 2001 Wiley‐Liss, Inc.