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t(14;19)(q32;q13): A recurrent translocation in B‐cell precursor acute lymphoblastic leukemia
Author(s) -
Robinson Hazel M.,
Taylor Kerry E.,
Jalali G. Reza,
Cheung Kan Luk,
Harrison Christine J.,
Moorman Anthony V.
Publication year - 2004
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.10299
Subject(s) - chromosomal translocation , breakpoint , fluorescence in situ hybridization , chronic lymphocytic leukemia , leukemia , acute lymphocytic leukemia , biology , cytogenetics , microbiology and biotechnology , immunophenotyping , gene rearrangement , b cell , cancer research , gene , lymphoblastic leukemia , immunology , genetics , flow cytometry , antibody , chromosome
The recurrent t(14;19)(q32;q13) translocation associated with chronic B‐cell lymphoproliferative disorders, such as atypical chronic lymphocytic leukemia, results in the juxtaposition of the IGH@ and BCL3 genes and subsequent overexpression of BCL3 . We report six patients with B‐cell precursor acute lymphoblastic leukemia who have a cytogenetically identical translocation with different breakpoints at the molecular level. Fluorescence in situ hybridization with locus‐specific probes confirmed the involvement of the IGH @ gene but showed that the breakpoint on 19q13 lay outside the region documented in t(14;19)(q32;q13)‐positive chronic lymphocytic leukemia. This newly described translocation constitutes a distinct cytogenetic subgroup that is confined to older children and younger adults with B‐cell precursor acute lymphoblastic leukemia. © 2003 Wiley‐Liss, Inc.