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Mutations of the BIK gene in human peripheral B‐cell lymphomas
Author(s) -
Arena Vincenzo,
Martini Maurizio,
Luongo Myriam,
Capelli Arnaldo,
Larocca Luigi Maria
Publication year - 2003
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.10245
Subject(s) - gene , peripheral , biology , genetics , computational biology , medicine
BIK, a BH (Bcl2 homology domain)3‐only protein, is a proapoptotic member of the BCL2 family. We performed single‐strand conformational polymorphism and sequencing analysis of the entire coding region of the BIK gene (exons 2–5) in 71 B‐cell lymphomas [27 follicular lymphomas (FLs), 13 marginal cell lymphomas (MZLs), 7 small lymphocytic lymphomas (SLLs), 6 mantle cell lymphomas (MCLs), 2 lymphoplasmacytic lymphomas, and 16 diffuse large B‐cell lymphomas (DLBCLs)]. Missense BIK gene mutations were observed in 3 of 27 (11%) FLs, in 2 of 13 (15%) MZLs, and in 1 of 16 (6%) DLBCLs. Sequence alterations in intronic regions were observed in 4 of 27 (14.8%) FLs, in 7 of 13 (53%) MZLs, and in 3 of 16 (18%) DLBCLs. These data indicate that mutation of the BIK gene is a frequent feature of B‐cell lymphomas. © 2003 Wiley‐Liss, Inc.