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Both NUP98/TOP1 and TOP1/NUP98 transcripts are detected in a de novo AML with t(11;20)(p15;q11)
Author(s) -
Iwase Satsuki,
Akiyama Nobutake,
Sekikawa Tetsuaki,
Saito Shinobu,
Arakawa Yasuhiro,
HoriguchiYamada Junko,
Yamada Hisashi
Publication year - 2003
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.10239
Subject(s) - chromosomal translocation , breakpoint , myeloid leukemia , biology , cancer research , gene , intron , leukemia , fusion gene , acute leukemia , karyotype , microbiology and biotechnology , genetics , chromosome
The NUP98 gene is involved in several chromosomal abnormalities associated with acute leukemia. The recurrent t(11;20)(p15;q11) chromosomal translocation results in generation of the NUP98/TOP1 chimeric gene. This abnormality has been observed primarily in therapy‐related leukemias, and TOP1/NUP98 transcripts have not been demonstrated. We describe a case of de novo acute myeloid leukemia with t(11;20)(p15;q11), with no known history of exposure to chemicals. The translocation occurred in intron 13 of NUP98 and intron 7 of TOP1 , as in the three previously reported cases. The breakpoint in NUP98 was exactly the same as that found in a previously reported case. In addition, a reciprocal TOP1/NUP98 transcript was detected for the first time in our patient. © 2003 Wiley‐Liss, Inc.