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Genome‐wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation‐mediated fusion events
Author(s) -
Debernardi Silvana,
Lillington Debra M.,
Chaplin Tracy,
Tomlinson Simon,
Amess John,
Rohatiner Ama,
Lister T. Andrew,
Young Bryan D.
Publication year - 2003
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.10198
Subject(s) - karyotype , myeloid leukemia , biology , chromosomal translocation , fusion gene , homeobox , gene , genetics , microarray analysis techniques , microarray , chromosome , leukemia , gene expression , cancer research
Gene expression profiles were determined from presentation peripheral blood and bone marrow samples of 28 patients with acute myeloid leukemia (AML). Hierarchical clustering sorted the profiles into separate groups, each representing one of the major cytogenetic classes in AML [i.e., t(8;21), t(15;17), inv(16), 11q23, and normal karyotype]. Statistical group comparison identified genes whose expression was strongly correlated with these chromosomal classes. Moreover, the normal karyotype AMLs were characterized by distinctive up‐regulation of certain members of the class I homeobox A and B gene families, implying a common underlying genetic lesion. These data reveal novel diagnostic and therapeutic targets and demonstrate the potential of microarray‐based dissection of AML. © 2003 Wiley‐Liss, Inc.