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Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)
Author(s) -
La Starza Roberta,
Trubia Maurizio,
Crescenzi Barbara,
Matteucci Caterina,
Negrini Massimo,
Martelli Massimo F.,
Pelicci Pier Giuseppe,
Mecucci Cristina
Publication year - 2003
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.10182
Subject(s) - chromosomal translocation , homeobox a1 , homeobox , myeloid leukemia , biology , gene , fusion gene , breakpoint , fluorescence in situ hybridization , cancer research , hnf1b , myeloid , homeobox protein nkx 2.5 , microbiology and biotechnology , gene cluster , runx1t1 , genetics , gene expression , chromosome
The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15;q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was involved in the translocation. At 12q13, the breakpoint fell within BAC 578A18, selected for the homeobox C ( HOXC ) cluster genes. RACE‐PCR showed that HOXC13 was the partner gene of NUP98 . To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies. © 2003 Wiley‐Liss, Inc.