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t(10;16)(q22;p13) and MORF ‐ CREBBP fusion is a recurrent event in acute myeloid leukemia
Author(s) -
Vizmanos José L.,
Larráyoz María J.,
Lahortiga Idoya,
Floristán Filomena,
Álvarez Carmen,
Odero María D.,
Novo Francisco J.,
Calasanz María J.
Publication year - 2003
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.10174
Subject(s) - myeloid leukemia , chromosomal translocation , fusion gene , karyotype , leukemia , medicine , biology , cancer research , gene , genetics , chromosome
Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF ‐ CREBBP fusion in an 84‐year‐old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML. © 2003 Wiley‐Liss, Inc.