t(10;16)(q22;p13) and  MORF ‐ CREBBP  fusion is a recurrent event in acute myeloid leukemia | Zendy

Vizmanos José L. | Zendy; Larráyoz María J. | Zendy; Lahortiga Idoya | Zendy; Floristán Filomena | Zendy; Álvarez Carmen | Zendy; Odero María D. | Zendy; Novo Francisco J. | Zendy; Calasanz María J. | Zendy

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t(10;16)(q22;p13) and MORF ‐ CREBBP fusion is a recurrent event in acute myeloid leukemia

Author(s) -

Vizmanos José L.,

Larráyoz María J.,

Lahortiga Idoya,

Floristán Filomena,

Álvarez Carmen,

Odero María D.,

Novo Francisco J.,

Calasanz María J.

Publication year - 2003

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.10174

Subject(s) - myeloid leukemia , chromosomal translocation , fusion gene , karyotype , leukemia , medicine , biology , cancer research , gene , genetics , chromosome

Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF ‐ CREBBP fusion in an 84‐year‐old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML. © 2003 Wiley‐Liss, Inc.

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