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Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)
Author(s) -
Dal Cin Paola,
Quade Bradley J.,
Neskey David M.,
Kleinman Michael S.,
Weremowicz Stanislawa,
Morton Cynthia C.
Publication year - 2003
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.10159
Subject(s) - smooth muscle , leiomyomatosis , leiomyoma , uterine leiomyoma , intrusion , medicine , pathology , geochemistry , geology
Abstract Intravenous leiomyomatosis (IVL) is a rare smooth‐muscle proliferation that is of special interest because of its quasi‐malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15‐qter and/or loss of 14q24‐qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation. © 2003 Wiley‐Liss, Inc.