Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24) | Zendy

Dal Cin Paola | Zendy; Quade Bradley J. | Zendy; Neskey David M. | Zendy; Kleinman Michael S. | Zendy; Weremowicz Stanislawa | Zendy; Morton Cynthia C. | Zendy

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Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)

Author(s) -

Dal Cin Paola,

Quade Bradley J.,

Neskey David M.,

Kleinman Michael S.,

Weremowicz Stanislawa,

Morton Cynthia C.

Publication year - 2003

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.10159

Subject(s) - smooth muscle , leiomyomatosis , leiomyoma , uterine leiomyoma , intrusion , medicine , pathology , geochemistry , geology

Intravenous leiomyomatosis (IVL) is a rare smooth‐muscle proliferation that is of special interest because of its quasi‐malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15‐qter and/or loss of 14q24‐qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation. © 2003 Wiley‐Liss, Inc.

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