Breakpoint characterization of der(9) deletions in chronic myeloid leukemia patients | Zendy

Storlazzi Clelia T. | Zendy; Specchia Giorgina | Zendy; Anelli Luisa | Zendy; Albano Francesco | Zendy; Pastore Domenico | Zendy; Zagaria Antonella | Zendy; Rocchi Mariano | Zendy; Liso Vincenzo | Zendy

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Breakpoint characterization of der(9) deletions in chronic myeloid leukemia patients

Author(s) -

Storlazzi Clelia T.,

Specchia Giorgina,

Anelli Luisa,

Albano Francesco,

Pastore Domenico,

Zagaria Antonella,

Rocchi Mariano,

Liso Vincenzo

Publication year - 2002

Publication title -

genes, chromosomes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.754

H-Index - 119

eISSN - 1098-2264

pISSN - 1045-2257

DOI - 10.1002/gcc.10116

Subject(s) - derivative chromosome , breakpoint , chromosomal translocation , myeloid leukemia , biology , chromosome , genetics , microbiology and biotechnology , chromosome 22 , gene , cancer research

Deletions adjacent to the 9/22 translocation breakpoint on the derivative chromosome 9 have recently been described in a substantial number of chronic myeloid leukemia (CML) cases, but their extension has not been characterized in detail. Using FISH with an appropriate set of BAC/PAC probes, we have characterized the deletion in 10 CML cases, identified by screening 71 patients at diagnosis. Five patients showed a complex chromosome rearrangement and 3 of them were deleted. The size of the deletion was variable, ranging from few hundreds kb to 8 Mb. A minimally deleted region on both chromosomes 9 and 22 was identified and was found to contain the ASS gene on chromosome 9 and IGLL1 on chromosome 22. © 2002 Wiley‐Liss, Inc.

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