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Genome profiles of familial/bilateral and sporadic testicular germ cell tumors
Author(s) -
Kraggerud Sigrid Marie,
Skotheim Rolf I.,
Szymanska Jadwiga,
Eknæs Mette,
Fosså Sophie D.,
Stenwig Anna E.,
Peltomäki Päivi,
Lothe Ragnhild A.
Publication year - 2002
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.10058
Subject(s) - germ cell , biology , genome , germ cell tumors , germ , genetics , gene , microbiology and biotechnology , chemotherapy
In order to investigate the genetics of testicular germ cell tumors (TGCTs), we examined 33 TGCTs, including 15 familial/bilateral and 18 sporadic tumors, using comparative genomic hybridization. The frequencies of the histological subtypes were comparable between the two groups. Gains of the whole or parts of chromosome 12 were found in 30 tumors (91%). Furthermore, increased copy number of the whole or parts of chromosomes 7, 8, 17, and X, and decreased copy number of the whole or parts of chromosomes 4, 11, 13, and 18 were observed in ≥50% of the tumors. Sixteen smallest regions of overlapping changes were delineated on 12 different chromosomes. The chromosomal copy numbers of familial/bilateral and sporadic TGCTs were comparable, suggesting similar genetic pathways to disease in both groups. However, significant differences were observed between the two main histological subgroups. Gains from 15q and 22q were associated with seminomas ( P = 0.005 and P = 0.02, respectively), whereas gain of the proximal 17q (17q11.2–21) and high‐level amplification from chromosome arm 12p, and losses from 10q were associated with nonseminomas ( P < 0.001, P = 0.04, and P = 0.03, respectively). © 2002 Wiley‐Liss, Inc.