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Determination of a minimal deletion interval on chromosome band 8p21 in sporadic prostate cancer †
Author(s) -
Swalwell Jennifer I.,
Vocke Cathy D.,
Yang Youfeng,
Walker Jonathan R.,
Grouse Lynette,
Myers Stuart H.,
Gillespie John W.,
Bostwick David G.,
Duray Paul H.,
Linehan W. Marston,
EmmertBuck Michael R.
Publication year - 2002
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/gcc.10015
Subject(s) - biology , prostate cancer , chromosome , genetics , chromosome band , microdissection , microsatellite , gene , allele , cancer , gene mapping
Loss of the short arm of chromosome 8 is a common event in prostatic neoplasms. Previous studies indicate that there may be up to three separate tumor suppressor genes on chromosome arm 8p, based on patterns of allelic loss. The responsible gene or genes have yet to be identified. In the present study, we used laser‐capture microdissection of primary human prostate tumors and 17 microsatellite markers across chromosome band 8p21 to determine a minimal deletion interval. From an initial set of 120 cases, three tumors contained overlapping interstitial deletions on chromosome band 8p21. The three cases define an internally consistent minimal candidate tumor suppressor gene interval of approximately two megabases. Published 2002 Wiley‐Liss, Inc.