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Modeling and simulation of human induced pluripotent stem cell‐derived cardiac tissue
Author(s) -
Jung Alexander,
Staat Manfred
Publication year - 2019
Publication title -
gamm‐mitteilungen
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.239
H-Index - 18
eISSN - 1522-2608
pISSN - 0936-7195
DOI - 10.1002/gamm.201900002
Subject(s) - induced pluripotent stem cell , electromechanics , workflow , biomedical engineering , human heart , tissue engineering , computer science , parameterized complexity , finite element method , stem cell , drug discovery , biological system , microbiology and biotechnology , neuroscience , computational biology , engineering , embryonic stem cell , chemistry , biology , bioinformatics , mechanical engineering , medicine , cardiology , biochemistry , structural engineering , algorithm , database , gene
Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) have become a promising in vitro model for human native cardiomyocytes. Cultivated tissue samples beat autonomously and can be used for basic and pharmacological research. For mechanical measurements of these tissue samples, the CellDrum technology has been developed. Measurements are extended by simulations with a multi‐scale electromechanically coupled finite element method based model. This model can be parameterized and validated experimentally. The paper describes the model, its workflow, and preliminary simulations to study the effect of fibroblasts and a selected cardiac drug on the electromechanics of hiPSC‐CMs.