Open Access6‐Gingerol, an active pungent component of ginger, inhibits L‐type Ca 2+ current, contractility, and Ca 2+ transients in isolated rat ventricular myocytes
Author(s) -
Han Xue,
Zhang Yuanyuan,
Liang Yingran,
Zhang Jianping,
Li Mengying,
Zhao Zhifeng,
Zhang Xuan,
Xue Yurun,
Zhang Ying,
Xiao Jingkai,
Chu Li
Publication year - 2019
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.968
Subject(s) - contractility , myocyte , chemistry , intracellular , gingerol , patch clamp , pharmacology , medicine , endocrinology , biophysics , biochemistry , biology , food science , receptor
Ginger has been widely used as a flavor, food, and traditional medicine for centuries. 6‐Gingerol (6‐Gin) is the active components of ginger and offers some beneficial effects on cardiovascular diseases. Here, the effects of 6‐Gin on L‐type Ca 2+ current (I Ca‐L ), contractility, and the Ca 2+ transients of rat cardiomyocytes, were investigated via patch‐clamp technique and the Ion Optix system. The 6‐Gin decreased the I Ca‐L of normal and ischemic ventricular myocytes by 58.17 ± 1.05% and 55.22 ± 1.34%, respectively. 6‐Gin decreased I Ca‐L in a concentration‐dependent manner with a half‐maximal inhibitory concentration (IC 50 ) of 31.25 μmol/L. At 300 μmol/L, 6‐Gin reduced the cell shortening by 48.87 ± 5.44% and the transients by 42.5 ± 9.79%. The results indicate that the molecular mechanisms underlying the cardio‐protective effects of 6‐Gin may because of a decreasing of intracellular Ca 2+ via the inhibition of I Ca‐L and contractility in rat cardiomyocytes.