Open AccessImproving antioxidant and antiproliferative activities of colla corii asini hydrolysates using ginkgo biloba extracts
Author(s) -
Xu Xiaobing,
Guo Shangwei,
Hao Xianghui,
Ma Hui,
Bai Yanping,
Huang Yaqin
Publication year - 2018
Publication title -
food science and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 27
ISSN - 2048-7177
DOI - 10.1002/fsn3.587
Subject(s) - ginkgo biloba , chemistry , traditional medicine , antioxidant , antioxidant capacity , pharmacology , medicine , biochemistry
Colla corii asini hydrolysates ( ACCH ) and ginkgo biloba extracts ( EG b) possess more potent antioxidant effects when used in combination than when used alone. The mixture of ACCH and EG b at a dose ratio of 20:4(w:w) showed the highest radical scavenging activity with IC 50 of 0.17 ± 0.01, 0.43 ± 0.02 and 1.52 ± 0.07 mg/ml against DPPH , ABTS and HO · free radicals, respectively. Furthermore, the inhibition of breast cancer cells MCF ‐7 and MDA ‐ MB ‐231 proliferation increased when these cell lines were treated with a combination of ACCH and EG b for 72 hr, with IC 50 of 4.32 ± 0.12 mg/ml and 0.39 ± 0.01 mg/ml, respectively. The findings indicated that the mixtures of ACCH and EG b could be used to prevent and treat some diseases caused by the excessive free radicals, especially cancer. Therefore, the mixtures of ACCH and EG b might serve as a natural source of desirable antioxidant and anticancer agents for the nutraceutical and pharmaceutical industries.